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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophyor other serious illnesses, such as cancer or glaucoma. In the past, muscle loss has typically been used to justify anabolic steroid use in an elderly patient (and to the extent that used to justify anabolic steroid use, the older patient's use of steroids has had to be taken into account). Therefore, the study's objectives were to determine whether anabolic steroid use or no use for an elderly population can be used to determine whether muscle loss and muscle wasting occur during aging without the use of steroids, and to investigate the effects of aging on the expression of the gene regulating gene transcription [13, 13(14–16)]. The study's primary hypotheses were: 1) that muscle loss and muscle wasting can be reliably distinguished by examining changes in the expression of genes involved in protein synthesis; and 2) that this type of expression profile is consistent for men and women, so that changes in muscle mass and strength can be used as a measure of aging. The study's design was to evaluate the effects of aging on muscle mass of an elderly and non-elderly group. Using a 2.5-year-old child who is considered an ideal subject to determine whether a gene has changed with age, the study's objective was to determine whether muscle loss and muscle wasting are associated with an increase in the expression of genes involved in protein synthesis. Previous studies assessing the effects of aging on protein synthesis genes  and their impact on the regulation of mTOR and PKB have been published. All subjects in the current study were recruited from a general community and from a nursing home, where an elderly client had recently received an injection of steroid and was undergoing physical therapy. No other elderly subjects were used in this study. Subjects in this study were recruited and screened using standardized procedures to exclude subjects with medical and psychiatric problems, those with compromised health, young adults (age less than 25), and individuals with known disease and/or condition. The study was approved by the McGill University Ethics Committee. The first cohort of subjects was recruited from September 2001 to May 2005 with participants recruited via a newspaper appeal to the local health centre and to the community, as well as through internet advertisements after their application was considered. The subjects involved in the current study were referred to the university in September 2005. The trial was approved by Health Canada's Institutional Review Board at McGill University. The research protocol and study data (including subjects' personal information) have been reported in full in The New England Journal of Medicine, Vol 369 Related Article: